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Alagille Syndrome

Alagille syndrome (ALGS) is a rare, multisystem genetic disorder that can affect the liver, heart, skeleton, eyes, central nervous system, kidneys and facial features. The estimated incidence of ALGS ranges from 1 in 30,000 to 50,000 live births. Liver damage is caused by a paucity of bile ducts preventing bile flow from the liver to the small intestine. Approximately 95% of patients with the condition present with chronic cholestasis, usually within the first three months of life, and as many as 88% also present with severe, intractable pruritus.

To learn more about ALGS, including what causes the disease, the common signs and symptoms and how it is diagnosed, download our fact sheet and infographic below.

For additional ALGS information and resources, visit the Alagille Syndrome Alliance.

This is not an exhaustive list of organizations. Albireo assumes no responsibility for information or statements on external websites.